Programme

DATE

2025/6/19 – 2025/6/21

LOCATION

N1 – Multifunction Hall

LANGUAGE

English

BOOKLET

MoE-FSCPO/SUAT Joint Workshop/Symposium on Cancer Biology

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BOOKLET

11th Macau Symposium on Biomedical Sciences 2025

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08:30 – 09:00

Registration / Guest Reception

Opening Ceremony of
the 10th Macau Symposium on Biomedical Sciences

09:00 – 09:30

Welcome Remarks delivered by

Prof. Wei GE
Vice Rector (Research) of the University of Macau

Programme Introduction delivered by

Prof. Chuxia DENG
Dean of the Faculty of Health Sciences of the University of Macau

Group Photo

Plenary Session

Session Chair

Chuxia DENG
University of Macau

09:30 – 10:10

Discovery of Novel Mechanisms to Enhance Efficacy for Anti-cancer Immunotherapy

Xiao-Fan WANG
Duke University
10:10 – 10:40

Strategies to Challenge Brain Metastasis Lethality and to Improve Quality of Life in Mice and Human

Manuel VALIENTE
Brain Metastasis Group of National Cancer Research Center
10:40 – 11:10

Detection, Function, and Regulation of Chromatin Loops

Keji ZHAO
National Heart, Lung, and Blood Institute (NHLBI)
11:10 – 11:40

Coffee Break & Poster Review
11:40 – 12:10

The Interaction between Systemic Metabolism and Ferroptosis Shapes T Cell Function in Immunity

Di YU
University of Queensland
12:10 – 12:40

Reconstituting Human Axial Development & Disease in Vitro

Cantas ALEV
Kyoto University

12:40 – 13:30

Luncheon (by invitation)

N1 – G006 Grand Plaza 萬豪軒

13:30 – 14:30

Poster Session

Session TWO

Stem Cell, Gene & Cell Therapy

Session Chair

Ren-He XU
University of Macau

Guokai CHEN
University of Macau

14:30 – 14:52

Hair follicle Stem Cells: From Basic Research To Clinical Trial

Jinyu LIU
Jilin University
14:52 – 15:14

Deciphering Single-cell m6A Methylome Landscape in Cell Fate Identity

Jonathan Yuin-Han LOH
A*STAR
15:14 – 15:36

Regenerative Medicine for Newborn Diseases

Paul Kwong-Hang TAM
Macau University of Sciences and Technology
15:36 – 16:00

hESC Derived MSCs for Therapeutic Application, Chimeric Study, and Cancer Research

Ren-He XU
University of Macau

16:00 – 16:30

Coffee Break & Poster Review

Session THREE

Fungal Biology, Infection and Application

Session Chair

Chris Koon Ho WONG
University of Macau

16:30 – 16:48

Sexual Development and Ascospore Formation of Aspergillus Nidulans

Kap-Hoon HAN
Woosuk University
16:48 – 17:06

Unveiling the Extended Phenotype: Linking Genes to Secondary Metabolites and Pathogen-host Interactions

Yit Heng CHOOI
The University of Western Australia
17:06 – 17:24

What Does a Fungal Pathogen Do to Survive and Grow inside a Macrophage?

Chris Koon Ho WONG
University of Macau
17:24 – 17:42

The Fungus Lurking inside Tumour

Ningning LIU
Shanghai Jiao Tong University
17:42 – 18:00

The Impact of Fungi in Space Exploration – Insights on Astromycology

Marta Filipa SIMÕES
Macau University of Science and Technology

19:00 – 21:00

Gala Dinner (by invitation)

Tromba Rija, Macau Tower 澳門旅遊塔會展娛樂中心地下皇家葡萄餚

08:30 – 09:00

Registration / Guest Reception

Opening Ceremony of
the 10th Macau Symposium on Biomedical Sciences

09:00 – 09:30

Welcome Remarks delivered by

Prof. Wei GE
Vice Rector (Research) of the University of Macau

Programme Introduction delivered by

Prof. Chuxia DENG
Dean of the Faculty of Health Sciences of the University of Macau

Group Photo

Plenary Session

Session Chair

Chuxia DENG
University of Macau

09:30 – 10:10

Discovery of Novel Mechanisms to Enhance Efficacy for Anti-cancer Immunotherapy

Xiao-Fan WANG
Duke University
10:10 – 10:40

Strategies to Challenge Brain Metastasis Lethality and to Improve Quality of Life in Mice and Human

Manuel VALIENTE
Brain Metastasis Group of National Cancer Research Center
10:40 – 11:10

Detection, Function, and Regulation of Chromatin Loops

Keji ZHAO
National Heart, Lung, and Blood Institute (NHLBI)
11:10 – 11:40

Coffee Break & Poster Review
11:40 – 12:10

The Interaction between Systemic Metabolism and Ferroptosis Shapes T Cell Function in Immunity

Di YU
University of Queensland
12:10 – 12:40

Reconstituting Human Axial Development & Disease in Vitro

Cantas ALEV
Kyoto University

12:40 – 13:30

Luncheon (by invitation)

N1 – G006 Grand Plaza 萬豪軒

13:30 – 14:30

Poster Session

Session TWO

Stem Cell, Gene & Cell Therapy

Session Chair

Ren-He XU
University of Macau

Guokai CHEN
University of Macau

14:30 – 14:52

Hair follicle Stem Cells: From Basic Research To Clinical Trial

Jinyu LIU
Jilin University
14:52 – 15:14

Deciphering Single-cell m6A Methylome Landscape in Cell Fate Identity

Jonathan Yuin-Han LOH
A*STAR
15:14 – 15:36

Regenerative Medicine for Newborn Diseases

Paul Kwong-Hang TAM
Macau University of Sciences and Technology
15:36 – 16:00

hESC Derived MSCs for Therapeutic Application, Chimeric Study, and Cancer Research

Ren-He XU
University of Macau

16:00 – 16:30

Coffee Break & Poster Review

Session THREE

Fungal Biology, Infection and Application

Session Chair

Chris Koon Ho WONG
University of Macau

16:30 – 16:48

Sexual Development and Ascospore Formation of Aspergillus Nidulans

Kap-Hoon HAN
Woosuk University
16:48 – 17:06

Unveiling the Extended Phenotype: Linking Genes to Secondary Metabolites and Pathogen-host Interactions

Yit Heng CHOOI
The University of Western Australia
17:06 – 17:24

What Does a Fungal Pathogen Do to Survive and Grow inside a Macrophage?

Chris Koon Ho WONG
University of Macau
17:24 – 17:42

The Fungus Lurking inside Tumour

Ningning LIU
Shanghai Jiao Tong University
17:42 – 18:00

The Impact of Fungi in Space Exploration – Insights on Astromycology

Marta Filipa SIMÕES
Macau University of Science and Technology

19:00 – 21:00

Gala Dinner (by invitation)

Tromba Rija, Macau Tower 澳門旅遊塔會展娛樂中心地下皇家葡萄餚

Session FOUR

Bioimaging and Biomaterials

Session Chair

Tzu-Ming LIU
University of Macau

Yunlu DAI
University of Macau

09:00 – 09:18

Nanoimmunochemistry: Modulating Tumour Immunosuppressive Microenvironment for Boosting Cancer Immunotherapy

Michael Chengzhong YU
University of Queensland
09:18 – 09:36

Innovative Formulation Engineering for Clinical Translation

Wei WEI
Institute of Process Engineering, Chinese Academy of Sciences
09:36 – 09:54

Short-wavelength Excitation Two-photon Microscopy of Endogenous Fluorophores in Biological Sample

Wei ZHENG
Shenzhen institutes of Advanced Technology, Chinese Academy of Sciences
09:54 – 10:12

Head-mounted Photoacoustic Fiberscopes for Cerebral Imaging on Freely Moving Mice

Long JIN
Jinan University
10:12 – 10:30

Label-free Diagnosis of Diabetes with Multiphoton Metabolic Imaging of Adipose Tissues

Tzu-Ming LIU
University of Macau

10:30 – 11:00

Coffee Break & Poster Review

Session FIVE

Chromatin and Transcription Regulation in Disease

Session Chair

Edwin Chong Wing CHEUNG
University of Macau

11:00 – 11:18

Histone Lysine Acylations and Their Critical Roles in Transcriptional Regulation and Diseases

Jiemin WONG
East China Normal University
11:18 – 11:36

Investigating the 3D Genome Organization of Super-silencers in the Human Genome

Melissa Jane FULLWOOD
Nanyang Technological University
11:36 – 11:54

Unraveling the Role of Non-canonical NF-ĸB Signalling in the Cancer Epigenome

Yinghui LI
Nanyang Technological University
11:54 – 12:12

New roles of Transcription Factors in Prostate Cancer Progression Revealed by Epigenetics and Liquid-liquid Phase Separation Analyses

Satoshi INOUE
Tokyo Metropolitan Institute for Geriatrics and Gerontology
12:12 – 12:30

Androgen Receptor Coregulator Function in Castrate Resistant Prostate Cancer

Edwin Chong Wing CHEUNG
University of Macau

12:30 – 13:30

Luncheon (by invitation)

N1 – G006 Grand Plaza 萬豪軒

13:30 – 14:00

Poster Session

14:00 – 14:30

Short Talks for Best Poster Awards

Session SIX

Cancer Research

Session Chair

Elaine Lai Han LEUNG
University of Macau

14:30 – 14:48

New Solutions for Lung Cancer Early Management

Wenhua LIANG
The First Affiliated Hospital of Guangzhou Medical University
14:48 – 15:06

Precision Engineering of the Human Gut Microbiome

Lei DAI
Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
15:06 – 15:24

Deregulation of RNA m6A Modification in Liver Cancer and its Therapeutic Potential

Jack Chun Ming WONG
University of Hong Kong
15:24 – 15:42

DRNPC: Natural Product-based Drug Combination and its Disease-specific Molecular Regulation

Xueni SUN
Hangzhou Normal University
15:42 – 16:00

Targeting Gut Microbiota and Application of Natural Product for Cancer Therapy

Elaine Lai Han LEUNG
University of Macau

16:00 – 16:30

Coffee Break & Poster Review

Session SEVEN

Technology Development and Cancer Research

Session Chair

Kai MIAO
University of Macau

16:30 – 16:48

Decoding RNA Dynamics and DNA (De)methylation: One Cell at a Time

Peng HU
Shanghai Ocean University
16:48 – 17:06

Knowledge-informed Deep Learning for Accurate Cell Status Annotation and Disease Diagnosis

Xiang YU
Shanghai Jiao Tong University
17:06 – 17:24

Trained Immunity in Chronic Inflammatory Diseases/Comorbidities and Tumours

Xiaofei LI
Shanghai Jiao Tong University
17:24 – 17:42

Impaired Endolysosomal Functions in Lewy Body Disorders

Qihui WU
Tongji University
17:42 – 18:00

Single Cell Lineage Tracing in Cancer Research

Kai MIAO
University of Macau

18:00 – 18:20

Best Poster Awards

Closing Ceremony of
the 10th Macau Symposium on Biomedical Sciences

Closing Speech by

Prof. Ren-He XU
Associate Dean (Research) of the Faculty of Health Sciences of the University of Macau

Pre-Opening Meeting: MoE-FSCPO/SUAT Joint Workshop/Symposium on Cancer Biology

14:00 – 14:20

Introduction of the Ministry of Education Frontiers Scientific Center for Precision Oncology (MoE-FSCPO) delivered by

Chuxia DENG
Dean, Faculty of Health Sciences, University of Macau

Introduction of Faculty of Synthetic Biology, Shenzhen University of Advanced Technology delivered by

Xian-En ZHANG
Dean, Faculty of Synthetic Biology, Shenzhen University of Advanced Technology

Session 1

14:20 – 16:20

Session Chair(s)

Xian-En ZHANG
Shenzhen University of Advanced Technology

Ping WEI
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences

14:20 – 14:40

Triple Negative Breast Cancer (TNBC): Its Formation and Potential Drivers

Chuxia DENG
University of Macau
14:40 – 15:00

Deciphering Tumor Evolution with DNA Barcoding-based Lineage Tracing

Zheng HU
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
15:00 – 15:20

A Strategy of Immune Cell Therapy based on Modification of the Local Tumor Microenvironment

Yong ZHAO
Shenzhen University of Advanced Technology
15:20 – 15:40

Microbe-assisted Synthesis of Polymeric Materials

Xuanjun ZHANG
University of Macau
15:40 – 16:00

Mesenchymal Stem Cells (MSCs) in Cancer: Friend or Foe?

Qizhou LIAN
Shenzhen University of Advanced Technology
16:00 – 16:20

Single-Cell Lineage Tracing Meets Evolutionary Phylogenetics in Breast Cancer Study

Kai MIAO
University of Macau

16:20 – 16:50

Coffee Break & Poster Review

Session 2

16:50 – 18:30

Session Chair(s)

Chuxia DENG
University of Macau

Lijun DI
University of Macau

16:50 – 17:10

Modular Design of T Cell Signaling for Cancer Immunotherapy

Ping WEI
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
17:10 – 17:30

Metal coordination nanomaterials for anticancer immunotherapy

Yunlu DAI
University of Macau
17:30 – 17:50

Extrachromosomal DNA Replication and Maintenance Couple with DNA Damage Pathway in Tumors

Haiyun GAN
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
17:50 – 18:10

Reciprocal Stabilization of CtBP and TRIM28 represses autophagy to promote metastasis

Lijun DI
University of Macau
18:10 – 18:30

Towards therapeutic development via reconstruction of gene editing systems

Yu WANG
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences

11th Macau Symposium on Biomedical Sciences 2025

08:30 – 09:00

Registration

09:00 – 09:20

Welcome Remark delivered by

Yonghua SONG
Rector, University of Macau

Programme Introduction delivered by

Chuxia DENG
Dean, Faculty of Health Sciences, University of Macau

Group Photo

Plenary Session (Keynote)

09:20 – 10:00

Session Chair(s)

Chuxia DENG
University of Macau

Ren-He XU
University of Macau

09:20 – 10:00

AIEgens: Conceptually New Bioprobes for Visualizing Biostructures and Monitoring Bioprocesses

Ben-Zhong TANG
The Chinese University of Hong Kong, Shenzhen

10:00 – 10:30

Coffee Break & Poster Session

Plenary Session

10:30 – 13:00

Session Chair(s)

Chuxia DENG
University of Macau

Ren-He XU
University of Macau

10:30 – 11:00

Infection, Cell Plasticity and Upper GI Cancers

Xin LU
University of Oxford
11:00 – 11:30

Fibroblastic Reticular Cells Control Immune Cell Activity and Interaction

Burkhard LUDEWIG
Cantonal Hospital St. Gallen
11:30 – 12:00

Membrane Atg8ylation and Its Manifestations

Vojo DERETIC
University of New Mexico
12:00 – 12:30

Novel CAR-T Cellular Therapy for Hematological Malignancies

He HUANG
Zhejiang University
12:30 – 13:00

Decoding TGF-β’s Paradox in Cancer

Xinhua FENG
Zhejiang University

13:00 – 14:30

Lunch Break & Poster Session

Session 1

Genome Biology (TBC)

14:30 – 16:00

Session Chair(s)

Edwin CHEUNG
University of Macau

Qihan CHEN
University of Macau

14:30 – 14:52

Precise RNA Targeting and Intervention

Chengqi YI
Peking University
14:52 – 15:14

Decode the Human Genome by Epigenetics in Cell-Free DNA and Single-Cells

Yaping LIU
Northwestern University
15:14 – 15:36

First Generation Spatially-Oriented Maps of Gastric Adenocarcinoma

Boon Ooi Patrick TAN
Duke-NUS Medical School
15:36 – 16:00

Dissecting Cancer Heterogeneity Toward Prevention Strategies

Jin-Xin BEI
Sun Yat-sen University

16:00 – 17:00

Coffee Break & Poster Review

Session 2

Neuroscience, Degenerative Diseases and Aging

17:00 – 18:30

Session Chair(s)

Wenhua ZHENG
University of Macau

Chen MING
University of Macau

Aifang CHENG
University of Macau

17:00 – 17:22

Pathogenesis and Early Diagnosis of Neurodegenerative Diseases

Keqiang YE
Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
17:22 – 17:44

APP Is Much More Than An Amyloid Precursor Protein

Karl HERRUP
University of Pittsburgh
17:44 – 18:06

Pathobiology of APOE in Aging and Alzheimer’s Disease

Guojun BU
The Hong Kong University of Science and Technology
18:06 – 18:30

Novel Mechanisms and Immunotherapy Strategy for Tau Pathogenesis

Yingjun ZHAO
Xiamen University

19:00 – 21:00

Gala Dinner by Invitation

Roosevelt D’ouro Restaurant

11th Macau Symposium on Biomedical Sciences 2025

08:30 – 09:00

Registration

Session 3

Stem Cell, Gene & Cell Therapy

09:00 – 10:00

Session Chair(s)

Guokai CHEN
University of Macau

Session Co-Chair(s)

Ren-He XU
University of Macau

09:00 – 09:20

MIR/SINE-Associated Enhancers Promote TGFβ1-Induced EMT in Lung Cancer Cells

Man ZHANG
Guangzhou National Laboratory
09:20 – 09:40

Xenogeneic Organ Regeneration and Long-Term In Vitro Embryo Culture

Jianguo ZHAO
Institute of Zoology, Chinese Academy of Sciences
09:40 – 10:00

Engineering Strategies for Immunocompatible Cell or Organ Allotransplantation

Xiaoqing ZHANG
Tongji University

Session 4

Frontiers of RNA Sequencing Technology

10:00 – 11:00

Session Chair(s)

Tzu-Ming LIU
University of Macau

Xiaofan DING
University of Macau

10:00 – 10:15

Spatial Transcriptomic Atlas Reveals Cellular Organization in the Octopus Brain and Implications for Cognitive Capabilities

Guangyi FAN
Qingdao Key Laboratory of Marine Genomics, BGI Research
10:15 – 10:30

AI-Driven mRNA Therapeutics: Algorithms and Applications

Liang ZHANG
Hangzhou Institute of Medicine, Chinese Academy of Sciences
10:30 – 10:45

Stereo-Seq, A High-Resolution and Large-Field Spatial Multi-Omics Technology

Ying HE
BGI-Shenzhen
10:45 – 11:00

Leveraging Single-Cell RNA-Seq and Organoid Technology for Establishing a Biosynthetic Food Safety Assessment System

Jian HE
Shanghai Jiao Tong University

11:00 – 11:30

Coffee Break & Poster Session

Session 5

Tumor Immunology and Immunotherapy

11:30 – 13:00

Session Chair(s)

Qi ZHAO
University of Macau

Zhenghai TANG
University of Macau

11:30 – 11:48

Phase-Separated Molecular Coacervates for Intracellular Delivery and Immunotherapies

Jiang XIA
The Chinese University of Hong Kong
11:48 – 12:06

Targeting Airway Epithelial Cells to Translate Mechanism into Therapy

MIngtao Roger LIANG
University of Newcastle
12:06 – 12:24

Macrophage and Tumour Immune Micro-Environment

Jun CHEN
Sun Yat-sen University
12:24 – 12:42

Regulation of Lipid Metabolism in Tumour-Infiltrating CD8+ T Cells

Jun GUI
Shanghai Jiao Tong University
12:42 – 13:00

Functions of Microglia in Alzheimer’s Disease

Shoutang WANG
The University of Hong Kong

13:00 – 14:30

Lunch Break & Poster Session

Session 6

Biomaterials and Nanomedicine

14:30 – 15:30

Session Chair(s)

Yunlu DAI
University of Macau

Bei LI
University of Macau

14:30 – 14:50

Microneedle Technology for Intradermal Cell Delivery

Chenjie XU
City University of Hong Kong
14:50 – 15:10

Oxyberberine Nanoparticle as a Novel Agent for Alzheimer’s Disease: Evaluation of Its Efficacy and Molecular Mechanisms

Yanfang XIAN
The Chinese University of Hong Kong
15:10 – 15:30

Smart Nanomedicines Acting on Tumour Vessel Microenvironment

Suping LI
National Center for Nanosscience and Technology, University of Chinese Academy of Sciences

15:30 – 16:30

Coffee Break & Poster Review

Session 7

Fungi in One Health

16:30 – 18:00

Session Chair(s)

Koon Ho Chris WONG
University of Macau

Session Co-Chair(s)

Marta Filipa SIMÕES
Macau University of Science and Technology

16:30 – 16:48

Host-Induced Fungicide Phenotypic Resistance

Linqi WANG
Institute of Microbiology, Chinese Academy of Sciences
16:48 – 17:06

Insight into Fungal Pathogenicity Driven by Regulation of Secondary Metabolism

Wenbing YIN
Institute of Microbiology, Chinese Academy of Sciences
17:06 – 17:24

Mandimycin: A New Polyene Macrolide Antifungal with a Unique Mode of Action

Zhuo SHANG
Shandong University
17:24 – 17:42

Fungi and Cancer: From Gut to Intratumour

Ningning LIU
Shanghai Jiao Tong University
17:42 – 18:00

A Gut Fungal Symbiont Activates Intestinal Regeneration

Chen DING
Northeastern University

18:00 – 18:30

Presentation of Selected Posters

Best Poster Awards

Closing Ceremony